Occult breast cancer

Case Courtesy of​

Dr / Neven R. Fares

Radiology Consultant, Minia Oncology Center, Egypt.

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Breast Imaging
Metastatic occult breast cancer presented initially by mediastinal & abdominal lymphadenopathy.
  • 70 years old female complaining of vague abdominal pain.
  • Abdominal ultrasound (not shown): abdominal lymphadenopathy and multiple hepatic focal lesions.

Metastatic Workup

  • Contrast-enhanced CT chest axial cut, mediastinal window [Fig 01]: lobulated nodal masses at anterior mediastinum distributed at the region of internal mammary nodal groups bilaterally (black arrow). Incidentally detected left breast mass with mild skin thickening (white bold arrow)
  • Contrast-enhanced CT upper abdomen, axial cuts [Fig 02]: hepatic focal lesions (white arrow) and sizable para-aortic infiltrated lymph nodes (black arrow)
  • Diagnostic Mammography MLO & CC views [Fig 03]: Multiple small masses scattered at both breasts with minimally increased skin thickening of the left breast (Black arrows).
  • Targeted Ultrasound of left breast [Fig 04]: upper inner quadrant lobulated hypoechoic mass seen para-median in location with other tiny masses seen bilaterally (white arrows)
  • The deeply-seated irregular mass seen at the left breast was targeted by ultrasound and a biopsy was taken.
  • Histopathology: undifferentiated carcinoma and Immunophenotyping revealed malignant ductal origin.
  • Occult breast cancers comprise a small portion of breast cancers but should be recognized.
  • Careful examination of the breast should be a routine part of chest CT examination and further referral to a breast imaging unit with any detected abnormality.